RABBIT ANTI ATG5-ATG12 COMPLEX (C-TERMINAL)

• CAS Number:

  9007-83-4

• Gene Name:

  [ATG5-ATG12]

• NCBI Gene ID:

  9140

• Reactivity:

  Human

• Storage Conditions:

  Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.

• Specificity:

  This item specifically recognises an epitope within the C-Terminal (CT) region of the Atg5-Atg12 complex, which plays a key role in the regulation of autophagy, and is emerging as an important factor in the innate immune response to viruses.
  
  Studies have shown that the Atg5-Atg12 complex directly interacts with RIG-1 (retinoic acid-inducible gene 1) and the adaptor molecule IPS-1 (IFN-beta promoter stimulator 1), through caspase recruitment domains (CARDs), thereby acting as a negative regulator of the type I IFN production pathway, and as a contributor to RNA viral replication within the host cells.

• Other Gene Names:

  [ATG12; ATG12; APG12; FBR93; APG12L; HAPG12; APG12; APG12L; APG12-like]

• Short Name:

  [ATG5-ATG12 COMPLEX]

• Other Product Names:

  [ubiquitin-like protein ATG12 isoform 1; Ubiquitin-like protein ATG12; ubiquitin-like protein ATG12; ATG12 autophagy related 12 homolog; Apg12 (autophagy, yeast) homolog; autophagy related 12; Autophagy-related protein 12; APG12-like]

• NCBI GI Number:

  290560746

• NCBI Accession Number:

  NP_004698.3

• NCBI GB Accession Number:

  NM_004707.3