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Mitochonic acid 5

CAT: 0013-GTR19157860-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157860-01Size:200 mg
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Description
Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases.Treatment with MA-5 reduced mitochondrial apoptosis via upregulation of mitophagy. Increased mitophagy degraded damaged mitochondria, disrupting mitochondrial apoptosis, neutralizing ROS overproduction, and improving cellular energy production. We also identified that MA-5 regulated mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway. Inhibiting this signaling pathway or knocking down Bnip3 expression prevented MA-5 from having beneficial effects on mitochondrial homeostasis and increased microglial apoptosis.
CAS Number
1354707-41-7
Product Name Alternative
MA-5
Purity
>98% (HPLC)
Solubility
DMSO:95 mg/mL (288.49 mM)
Smiles
OC (=O) C (CC (=O) C1=C (F) C=C (F) C=C1) C1=CNC2=CC=CC=C12
Molecular Formula
C18H13F2NO3
Molecular Weight
329.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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Alternative Products

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T24470-01Mitochonic Acid 35
M22041-01Mitochonic acid 5
A16888-10Mitochonic acid 5 10mg
A16888-1Mitochonic acid 5 1mg
A16888-100Mitochonic acid 5 100mg
A16888-25Mitochonic acid 5 25mg
A16888-5Mitochonic acid 5 5mg
A16888-50Mitochonic acid 5 50mg
S0881-100mgMitochonic acid 5 (MA-5)

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