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RABBIT ANTI HUWE1

CAT: 0544-MBS223881-01Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS223881-01Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
[HUWE1]
NCBI Gene ID
10075
Reactivity
Mouse, Rat
Storage Conditions
Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Specificity
This item specifically recognises human HUWE1, a 148kDa DNA binding protein.
HUWE1 is a novel E3 ubiquitin-protein ligase involved with mediating ubiquitination and subsequent proteasomal degradation of target proteins.
HUWE1 is involved in apoptosis through catalyzation of the polyubiquitination and degradation of MCL1, ubiquitination of the p53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Research indicates that HUWE1 regulates the abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.
Other Gene Names
[HUWE1; HUWE1; MULE; Ib772; LASU1; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272; KIAA0312; KIAA1578; UREB1; ARF-BP1; HectH9; LASU1; Mule; URE-B1; URE-binding protein 1]
Short Name
[HUWE1]
Other Product Names
[E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase HUWE1; ARF-binding protein 1; BJ-HCC-24 tumor antigen; HECT domain protein LASU1; Mcl-1 ubiquitin ligase E3; URE-binding protein 1; homologous to E6AP carboxyl terminus homologous protein 9; large structure of UREB1; upstream regulatory element-binding protein 1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; ARF-binding protein 1; ARF-BP1; HECT, UBA and WWE domain-containing protein 1; Homologous to E6AP carboxyl terminus homologous protein 9; HectH9; Large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; Mule; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1]
NCBI GI Number
61676188
NCBI Accession Number
NP_113584.3
NCBI GB Accession Number
NM_031407.6
Uniprot Accession Number
Q7Z6Z7

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