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Spinorphin

CAT: 0013-GTR19157858-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157858-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.Spinorphin inhibited cytoplasmic Ca (2+) ([Ca (2+) ]i) transients, evoked by depolarization and capsaicin selectively in medium and small cultured rat DRG neurons. Spinorphin (10-300 M) inhibited the Ca (2+) signals in concentration dependant manner in small- and medium diameter DRG neurons. Capsaicin produced [Ca (2+) ]i responses only in small- and medium-sized DRG neurons, and pre-treatment with spinorphin significantly attenuated these [Ca (2+) ]i responses. Spinorphin significantly inhibited the functions of polymorphonuclear neutrophils (PMNs) by suppressing the binding of fMLF to its receptor on PMNs. Further, this inhibitor suppressed the carrageenan-induced accumulation of PMN in mouse air pouches after intravenous administration. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator. The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed.
CAS Number
137201-62-8
Purity
>98% (HPLC)
Smiles
CC (C) C[C@H] (N) C (=O) N[C@@H] (C (C) C) C (=O) N[C@@H] (C (C) C) C (=O) N[C@@H] (CC1=CC=C (O) C=C1) C (=O) N1CCC[C@H]1C (=O) N[C@@H] (CC1=CNC2=CC=CC=C12) C (=O) N[C@@H] ([C@@H] (C) O) C (O) =O
Molecular Formula
C45H64N8O10
Molecular Weight
877
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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