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Spinorphin

CAT: 0013-GTR19157858-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157858-01Size:200 mg
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Description
Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor.Spinorphin inhibited cytoplasmic Ca (2+) ([Ca (2+) ]i) transients, evoked by depolarization and capsaicin selectively in medium and small cultured rat DRG neurons. Spinorphin (10-300 M) inhibited the Ca (2+) signals in concentration dependant manner in small- and medium diameter DRG neurons. Capsaicin produced [Ca (2+) ]i responses only in small- and medium-sized DRG neurons, and pre-treatment with spinorphin significantly attenuated these [Ca (2+) ]i responses. Spinorphin significantly inhibited the functions of polymorphonuclear neutrophils (PMNs) by suppressing the binding of fMLF to its receptor on PMNs. Further, this inhibitor suppressed the carrageenan-induced accumulation of PMN in mouse air pouches after intravenous administration. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator. The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed.
CAS Number
137201-62-8
Purity
>98% (HPLC)
Smiles
CC (C) C[C@H] (N) C (=O) N[C@@H] (C (C) C) C (=O) N[C@@H] (C (C) C) C (=O) N[C@@H] (CC1=CC=C (O) C=C1) C (=O) N1CCC[C@H]1C (=O) N[C@@H] (CC1=CNC2=CC=CC=C12) C (=O) N[C@@H] ([C@@H] (C) O) C (O) =O
Molecular Formula
C45H64N8O10
Molecular Weight
877
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Spinorphin

Spinorphin is an oligopeptide.

CAS Number137201-62-8
PubChem CID3081832
IUPAC Name(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoic acid
Molecular FormulaC45H64N8O10
Molecular Weight877.0
XLogP1
Topological Polar Surface Area285
Hydrogen Bond Donor Count10
Hydrogen Bond Acceptor Count11
Rotatable Bond Count21
Heavy Atom Count63
Formal Charge0
Complexity1590
SMILES
C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N)O
InChI
InChI=1S/C45H64N8O10/c1-23(2)19-31(46)39(56)50-37(25(5)6)43(60)51-36(24(3)4)42(59)49-34(20-27-14-16-29(55)17-15-27)44(61)53-18-10-13-35(53)41(58)48-33(40(57)52-38(26(7)54)45(62)63)21-28-22-47-32-12-9-8-11-30(28)32/h8-9,11-12,14-17,22-26,31,33-38,47,54-55H,10,13,18-21,46H2,1-7H3,(H,48,58)(H,49,59)(H,50,56)(H,51,60)(H,52,57)(H,62,63)/t26-,31+,33+,34+,35+,36+,37+,38+/m1/s1
InChIKey
BXIFNVGZIMFBQB-DYDSHOKNSA-N
Chemical Structure
2D Structure
2D structure of Spinorphin
CAS: 137201-62-8
CID: 3081832
Formula: C45H64N8O10
MW: 877.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight877.0
XLogP31
Hydrogen Bond Donor Count10
Hydrogen Bond Acceptor Count11
Rotatable Bond Count21
Exact Mass876.47454027
Monoisotopic Mass876.47454027
Topological Polar Surface Area285 Ų
Heavy Atom Count63
Formal Charge0
Complexity1590
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-P1044Spinorphin
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A15314-50Spinorphin 50mg
350391Spinorphin Peptide
HY-P1044A-01Spinorphin (TFA)
GWB-BAC8F7Spinorphin Bovine

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