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Lindleyin

CAT: 0013-GTR19157853-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157853-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lindleyin is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ERalpha and ERbeta. The phytochemical Lindleyin, a major component of rhubarb, might contribute to this estrogenic activity through ERalpha and ERbeta. 4-Hydroxytamoxifen, an ER antagonist, completely reversed the estrogenic activity of Lindleyin. Lindleyin binds to ERalpha in vitro, as demonstrated using a fluorescent polarization assay. The in vivo effect of rhubarb extract was studied using a vitellogenin assay system in the freshwater fish, Japanese medaka (Oryzias latipes) . There were marked increases in serum vitellogenin levels in male medaka exposed to rhubarb extract.
CAS Number
59282-56-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (104.50 mM)
Smiles
CC (=O) CCC1=CC=C (O[C@@H]2O[C@H] (COC (=O) C3=CC (O) =C (O) C (O) =C3) [C@@H] (O) [C@H] (O) [C@H]2O) C=C1
Molecular Formula
C23H26O11
Molecular Weight
478.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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