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Nepodin

CAT: 0013-GTR19157852-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157852-01Size:200 mg
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Description
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 translocation via AMPK activation by nepodin.To obtain a novel modulator of glucose metabolism, we conducted screening of a small compound library in cultured L6 myotubes. We identified Nepodin that stimulated glucose uptake dose-dependently in differentiated L6 myotubes. The stimulatory effect of Nepodin on glucose uptake was abrogated by a 5'-adenosine monophosphate-activated protein kinase (AMPK) inhibitor. In addition, Nepodin stimulated the phosphorylation of AMPK. Nepodin also stimulated the translocation of GLUT4 to the plasma membrane in L6 myoblasts transfected with a Glut4 cDNA-coding vector and in differentiated L6 myotubes. In in vivo study, Nepodin suppressed the increases in fasting blood glucose levels and improved the glucose intolerance of C57BL/KsJ-db/db mice, a type 2 diabetic animal model. Nepodin rescued the impaired phosphorylation of AMPK in the skeletal muscle of db/db mice.
CAS Number
3785-24-8
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (578.09 mM)
Smiles
CC (=O) C1=C (O) C2=C (C=CC=C2O) C=C1C
Molecular Formula
C13H12O3
Molecular Weight
216.23
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Nepodin

Nepodin is a member of naphthols.

CAS Number3785-24-8
PubChem CID100780
IUPAC Name1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethanone
Molecular FormulaC13H12O3
Molecular Weight216.23
XLogP3.1
Topological Polar Surface Area57.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count16
Formal Charge0
Complexity276
SMILES
CC1=CC2=C(C(=CC=C2)O)C(=C1C(=O)C)O
InChI
InChI=1S/C13H12O3/c1-7-6-9-4-3-5-10(15)12(9)13(16)11(7)8(2)14/h3-6,15-16H,1-2H3
InChIKey
DMLHPCALHMPJHS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nepodin
CAS: 3785-24-8
CID: 100780
Formula: C13H12O3
MW: 216.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight216.23
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass216.078644241
Monoisotopic Mass216.078644241
Topological Polar Surface Area57.5 Ų
Heavy Atom Count16
Formal Charge0
Complexity276
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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