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RABBIT ANTI DAI

CAT: 0544-MBS223548-01Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS223548-01Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
[DAI]
NCBI Gene ID
81030
Storage Conditions
Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Specificity
This product recognizes human DAI, also known as Z-DNA Binding Protein (ZBP1), a 46kDa DNA binding protein belonging to a family of proteins that contain a Za domain which specifically binds to the left-handed Z-DNA and Z-RNA.

Initial studies suggested that DAI may be involved in processes such host response to neoplasia. Additional research has indicated that the cytosolic DAI can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of DAI to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK).

DAI is highly expressed in lymphatic tissues such as lymph nodes, leukocytes, tonsil, bone marrow and spleen. Expression at a lower level is also seen in thymus, lung and liver. It has been demonstrated that multiple isoforms of DAI exist.
Other Gene Names
[ZBP1; ZBP1; DAI; DLM1; DLM-1; C20orf183; C20orf183; DLM1]
Short Name
[DAI]
Other Product Names
[Z-DNA-binding protein 1 isoform b; Z-DNA-binding protein 1; Z-DNA-binding protein 1; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of IRFs; DNA-dependent activator of interferon regulatory factors; tumor stroma and activated macrophage protein DLM-1; Z-DNA binding protein 1; Tumor stroma and activated macrophage protein DLM-1]
NCBI GI Number
238550208
NCBI Accession Number
NP_001153889.1
NCBI GB Accession Number
NM_001160417.1
Uniprot Accession Number
Q9H171

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