Products for Research Use Only
RegisterLogin

Rogaratinib

CAT: 0013-GTR19157834-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19157834-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Rogaratinib is an aberrant inhibitor of fibroblast growth factor receptor (FGFR) . Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1, -2 and -3 kinase activity. A novel pan-FGFR inhibitor, rogaratinib, in biochemical, cellular and in vivo efficacy studies in a variety of preclinical cancer models. In vitro kinase activity assays demonstrate that rogaratinib potently and selectively inhibits the activity of FGFRs 1, 2, 3 and 4. In line with this, rogaratinib reduced proliferation in FGFR-addicted cancer cell lines of various cancer types including lung, breast, colon and bladder cancer. FGFR and ERK phosphorylation interruption by rogaratinib treatment in several FGFR-amplified cell lines suggests that the anti-proliferative effects are mediated by FGFR/ERK pathway inhibition.
CAS Number
1443530-05-9
Product Name Alternative
BAY1163877
Purity
>98% (HPLC)
Solubility
DMSO : 5.5 mg/mL (11.78 mM; Need ultrasonic)
Smiles
COCC1=C (CN2CCNC (=O) C2) N2N=CN=C (N) C2=C1C1=CC2=C (S1) C (OC) =CC (C) =C2
Molecular Formula
C23H26N6O3S
Molecular Weight
466.56
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
BA8936-5Rogaratinib
A16963-25Rogaratinib 25mg
A16963-10Rogaratinib 10mg
A16963-5Rogaratinib 5mg
A16963-100Rogaratinib 100mg
A16963-50Rogaratinib 50mg
A16963-2Rogaratinib 2mg
A16963-1Rogaratinib 1mg

Popular Products