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Gomisin J

CAT: 0013-GTR19157832-05Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157832-05Size:5 mg
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Description
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.Gomisin J attenuated lipid accumulation in OA-induced HepG2 cells. It also suppressed the expression of lipogenic enzymes and inflammatory mediators and increased the expression of lipolytic enzymes in OA-induced HepG2 cells. Furthermore, the use of specific inhibitors and fetuin-A siRNA and liver kinase B1 (LKB1) siRNA transfected cells demonstrated that gomisin J regulated lipogenesis and lipolysis via inhibition of fetuin-A and activation of an AMP-activated protein kinase (AMPK) -dependent pathway in HepG2 cells.
CAS Number
66280-25-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (257.43 mM)
Smiles
COc1c (O) cc2C[C@H] (C) [C@H] (C) Cc3cc (O) c (OC) c (OC) c3-c2c1OC
Molecular Formula
C22H28O6
Molecular Weight
388.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Gomisin J

Gomisin J is a tannin.

CAS Number66280-25-9
PubChem CID3001686
IUPAC Name(9S,10R)-3,4,15,16-tetramethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene-5,14-diol
Molecular FormulaC22H28O6
Molecular Weight388.5
XLogP4.6
Topological Polar Surface Area77.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity457
SMILES
C[C@@H]1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3C[C@@H]1C)O)OC)OC)OC)OC)O
InChI
InChI=1S/C22H28O6/c1-11-7-13-9-15(23)19(25-3)21(27-5)17(13)18-14(8-12(11)2)10-16(24)20(26-4)22(18)28-6/h9-12,23-24H,7-8H2,1-6H3/t11-,12+
InChIKey
PICOUNAPKDEPCA-TXEJJXNPSA-N
Chemical Structure
2D Structure
2D structure of Gomisin J
CAS: 66280-25-9
CID: 3001686
Formula: C22H28O6
MW: 388.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight388.5
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass388.18858861
Monoisotopic Mass388.18858861
Topological Polar Surface Area77.4 Ų
Heavy Atom Count28
Formal Charge0
Complexity457
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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