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Metformin

CAT: 0013-GTR19157820-06Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157820-06Size:500 mg
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Description
Metformin is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.Metformin is a first-line drug for the treatment of type 2 diabetes (T2D) and is often prescribed in combination with other drugs to control a patient's blood glucose level and achieve their HbA1c goal. (In Vitro) :Metformin (1,1-Dimethylbiguanide) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.Metformin (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 μM in cultured rat hepatocytes.Metformin shows cell viability and cytotoxic effects on PC-3 cells with IC50 of 5 mM. (In Vivo) :Metformin (1,1-Dimethylbiguanide; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with isoproterenol groups attenuates myocyte necrosis through histopathological analysis.Metformin (> 900 mg/kg/day, p.o.) results in moribundity/mortality and clinical signs of toxicity in Crl:CD (SD) rats.
CAS Number
657-24-9
Product Name Alternative
1,1-Dimethylbiguanide
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
In Vitro: H2O : 50 mg/mL (387.12 mM)
Smiles
CN (C) C (=N) NC (N) =N
Molecular Formula
C4H11N5
Molecular Weight
129.16
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Metformin

Metformin is a member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1. It has a role as a geroprotector, a hypoglycemic agent, a xenobiotic and an environmental contaminant. It is functionally related to a biguanide. It is a conjugate base of a metformin(1+).

CAS Number657-24-9
PubChem CID4091
IUPAC Name3-(diaminomethylidene)-1,1-dimethylguanidine
Molecular FormulaC4H11N5
Molecular Weight129.16
XLogP-1.3
Topological Polar Surface Area91.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count9
Formal Charge0
Complexity132
SMILES
CN(C)C(=N)N=C(N)N
InChI
InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
InChIKey
XZWYZXLIPXDOLR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Metformin
CAS: 657-24-9
CID: 4091
Formula: C4H11N5
MW: 129.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight129.16
XLogP3-1.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass129.10144537
Monoisotopic Mass129.10144537
Topological Polar Surface Area91.5 Ų
Heavy Atom Count9
Formal Charge0
Complexity132
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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