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ND-646

CAT: 0013-GTR19157818-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157818-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2 (IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively) ND-646-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras; Trp53-/- (also known as KRAS p53) and Kras; Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC.
CAS Number
1434639-57-2
Purity
>98% (HPLC)
Solubility
DMSO:95 mg/mL (167.06 mM)
Smiles
COc1ccccc1[C@H] (Cn1c2sc (-c3ncco3) c (C) c2c (=O) n (c1=O) C (C) (C) C (N) =O) OC1CCOCC1
Molecular Formula
C28H32N4O7S
Molecular Weight
568.64
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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