RABBIT ANTI RAT ALPHA SYNUCLEIN (pSer129)

• NCBI Gene ID:

  29219

• Reactivity:

  Bovine (Expected from Sequence), Dog (Expected from Sequence), Human (Expected from Sequence), Mouse (Expected from Sequence), Primate (Expected from Sequence)

• Storage Conditions:

  Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.

• Specificity:

  This item specifically recognises rat alpha synuclein when phosphorylated at Ser129. Alpha synuclein is a 140 amino acid, 15kDa protein seen predominantly in the neocortex, hippocampus, substantia nigra, thalamus and cerebellum. Its normal cellular function has not been definitively determined, but it is thought to be involved in the regulation of neuronal plasticity, dopamine neurotransmission and other membrane-associated processes at the presynaptic terminal. Alpha synuclein is normally a soluble, unfolded protein, but it can aggregate at high concentrations to form insoluble fibrils which, in association with other proteins such as ubiquitin, neurofilament protein and alpha B crystalline, form Lewy bodies. Lewy bodies are a hallmark pathological feature of Parkinson's disease and other neurodegenerative diseases. Alpha synuclein has several possible phosphorylation sites, Ser129 in particular can be phosphorylated by G-protein-coupled receptor kinases. Studies suggest that this phosphorylation promotes formation of alpha synuclein filaments, with hyperphosphorylation of Ser129 seen in Lewy bodies.

• Other Gene Names:

  [Snca; Snca]

• Short Name:

  [ALPHA SYNUCLEIN]

• Other Product Names:

  [alpha-synuclein; Alpha-synuclein; alpha-synuclein; synuclein, alpha (non A4 component of amyloid precursor)]

• NCBI GI Number:

  9507125

• NCBI Accession Number:

  NP_062042.1

• NCBI GB Accession Number:

  NM_019169.2

• Uniprot Accession Number:

  P37377

• CAS Number:

  9007-83-4