RABBIT ANTI ORAI3 (N-TERMINAL)

RABBIT ANTI ORAI3 (N-TERMINAL)

• CAS Number: 9007-83-4
• Gene Name: [ORAI3]
• NCBI Gene ID: 93129
• Reactivity: Mouse, Rat
• Storage Conditions: Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.
• Specificity: This item recognises human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family.
  
  Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
  
  ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.
  
  This item is not expected to cross react with either ORAI1 or ORAI2.
• Other Gene Names: [ORAI3; ORAI3; TMEM142C; TMEM142C]
• Short Name: [ORAI3]
• Other Product Names: [protein orai-3; Protein orai-3; protein orai-3; transmembrane protein 142C; ORAI calcium release-activated calcium modulator 3; Transmembrane protein 142C]
• NCBI GI Number: 22748651
• NCBI Accession Number: NP_689501.1
• NCBI GB Accession Number: NM_152288.2
• Uniprot Accession Number: Q9BRQ5