RABBIT ANTI ORAI1 (C-TERMINAL)
CAT:
544-MBS222945-01
Size:
0.1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
RABBIT ANTI ORAI1 (C-TERMINAL)
- CAS Number: 9007-83-4
- Gene Name: [ORAI1]
- NCBI Gene ID: 84876
- Reactivity: Mouse, Rat
- Storage Conditions: Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch. - Specificity: This item recognises human ORAI1, also known as Transmembrane protein 142A (TMEM142A), a 32.7 kDa multi-pass membrane protein belonging to the ORAI family.
Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
ORAI1 is a four- transmembrane spanning protein that is an essential component of CRAC. ORAI1 functions as a highly selective Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor.
Defective ORAI1 in humans is the cause of one form of hereditary severe combined immune deficiency (SCID), which results in ablated T-cell Ca2+ entry.
This item is not expected to cross react with either ORAI2 or ORAI3. - Other Gene Names: [ORAI1; ORAI1; IMD9; TAM2; ORAT1; CRACM1; TMEM142A; CRACM1; TMEM142A]
- Short Name: [ORAI1]
- Other Product Names: [calcium release-activated calcium channel protein 1; Calcium release-activated calcium channel protein 1; calcium release-activated calcium channel protein 1; calcium release-activated calcium modulator 1; protein orai-1; transmembrane protein 142A; ORAI calcium release-activated calcium modulator 1; Protein orai-1; Transmembrane protein 142A]
- NCBI GI Number: 38016943
- NCBI Accession Number: NP_116179.2
- NCBI GB Accession Number: NM_032790.3
- Uniprot Accession Number: Q96D31