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Tripolin A

CAT: 0013-GTR19157801-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157801-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase (Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively) Tripolin A, a non-ATP competitive inhibitor. Tripolin A reduced the localization of pAurora A on spindle microtubules (MTs), affected centrosome integrity, spindle formation and length, as well as MT dynamics in interphase, consistent with Aurora A inhibition by RNAi or other specific inhibitors, such as MLN8054 or MLN8237. Interestingly, Tripolin A affected the gradient distribution towards the chromosomes, but not the MT binding of HURP (Hepatoma Up-Regulated Protein), a MT-associated protein (MAP) and substrate of the Aurora A kinase. Therefore Tripolin A reveals a new way of regulating mitotic MT stabilizers through Aurora A phosphorylation.
CAS Number
1148118-92-6
Purity
>98% (HPLC)
Smiles
Oc3cc (/C=C1\c2ccccc2NC1=O) c (O) cc3
Molecular Formula
C15H11NO3
Molecular Weight
253.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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HY-124330Tripolin A
T208723-01Tripolin B
207427-01Tripolin A ((3E) -3-[ (2,5-Dihydroxyphenyl) methylene]-1,3-dihydro-2H-indol-2-one)
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