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FEN1 Inhibitor C2

CAT: 0013-GTR19157798-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157798-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1) FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate) -induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.
CAS Number
1995893-58-7
Product Name Alternative
FEN1-IN-4
Field of Research
Epigenetics & Chromatin; Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (430.59 mM; Need ultrasonic)
Smiles
On1c (=O) n (CC2CC2) c2ccccc2c1=O
Molecular Formula
C12H12N2O3
Molecular Weight
232.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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