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Deoxypodophyllotoxin

CAT: 0013-GTR19157795-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157795-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.Deoxypodophyllotoxin (DPT) induced both apoptosis and autophagy via production of mitochondrial reactive oxygen species (ROS) . DPT suppressed the PI3K/AKT/mTOR signaling cascades to lead autophagy process, resulting from conversion of light chain 3-I (LC3-I) into LC3-II and acidic vesicular organelles (AVOs) formation. Even if DPT-induced ROS were occurred in both apoptosis and autophagy, inhibition of ROS generation enhanced cell viability. Otherwise, 3-methyladeine (3-MA) impeding on autophagy accelerated an apoptotic response caused by DPT. Therefore, these findings suggest that DPT triggers cytoprotective autophagy against cytotoxic apoptosis.
CAS Number
19186-35-7
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (251.00 mM)
Smiles
[H][C@]12COC (=O) [C@]1 ([H]) [C@H] (c1cc (OC) c (OC) c (OC) c1) c1cc3OCOc3cc1C2
Molecular Formula
C22H22O7
Molecular Weight
398.41
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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