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Toceranib

CAT: 0013-GTR19157787-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157787-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Toceranib phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit (with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively), has antitumor and antiangiogenic activity.Administration of toceranib significantly decreased the number and percentage of Treg in the peripheral blood of dogs with cancer. Dogs receiving toceranib and CYC demonstrated a significant increase in serum concentrations of IFN-γ, which was inversely correlated with Treg numbers after 6 weeks of combination treatment.
CAS Number
356068-94-5
Product Name Alternative
SU11654, PHA 291639E
Purity
>98% (HPLC)
Solubility
DMSO:2.4 mg/mL (6.05 mM; Need ultrasonic)
Smiles
Cc1[nH]c (\C=C2/C (=O) Nc3ccc (F) cc23) c (C) c1C (=O) NCCN1CCCC1
Molecular Formula
C22H25FN4O2
Molecular Weight
396.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

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B1542-25Toceranib
205738Toceranib phosphate
HY-10330A-01Toceranib (phosphate)
TRC-T525502-100MGToceranib-d8
467694-01Toceranib discontinued

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