RABBIT ANTI 4EBP1 (C-TERMINAL)

RABBIT ANTI 4EBP1 (C-TERMINAL)

• CAS Number: 9007-83-4
• Gene Name: [4EBP1]
• NCBI Gene ID: 1978
• Reactivity: Mouse
• Storage Conditions: Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.
• Specificity: This item recognises an epitope within the C-terminal region (CT) of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1), a rapamycin-sensitive downstream target of TOR (Target of rapamycin), and regulatory factor of eukaryotic mRNA translation.
  
  The association between 4EPB1 and eukaryotic translation initiation factor 4E (eIF-4E) inhibits the binding of eIF-4E with p220, thereby preventing the formation of a functional eIF-4E complex, essential for mRNA translation. Phosphorylation of 4EBP1 following stimulation by mitogens such as insulin, results in the release of eIF-4E from 4EBP1, thereby enabling the translation complex to assemble.
  
  This item has been reported as suitable for use in IHC on mouse 3T3 cell cytospins.
• Other Gene Names: [EIF4EBP1; EIF4EBP1; BP-1; 4EBP1; 4E-BP1; PHAS-I; 4E-BP1; eIF4E-binding protein 1; PHAS-I]
• Short Name: [4EBP1]
• Other Product Names: [eukaryotic translation initiation factor 4E-binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1; eukaryotic translation initiation factor 4E binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I]
• NCBI GI Number: 4758258
• NCBI Accession Number: NP_004086.1
• NCBI GB Accession Number: NM_004095.3
• Uniprot Accession Number: Q13541