RABBIT ANTI TYROSINE HYDROXYLASE (pSer40)

• NCBI Gene ID:

  7054

• Reactivity:

  Human (Expected from Sequence), Mouse (Expected from Sequence), Pig (Expected from Sequence), Rat (Expected from Sequence)

• Storage Conditions:

  Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 12 months from date of despatch.

• Specificity:

  This item is specific for Tyrosine Hydroxylase, when phosphorylated at serine 40.
  
  Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthetic pathway of the catecholamines dopamine (DA), norepinephrine, and epinephrine. The enzyme exists as a tetramer, with each subunit composed of an N-terminal regulatory domain and a C-terminal catalytic domain.
  
  Phosphorylation of TH has been shown to occur at several serine residues. Phosphorylation at serine 40 results in an increase in hydroxylase activity, and phosphorylation at serine 19 is reported to promote phosphorylation of the serine 40 residue.
  
  Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.

• Other Gene Names:

  [TH; TH; TYH; DYT14; DYT5b; TYH; TH]

• Short Name:

  [TYROSINE HYDROXYLASE]

• Other Product Names:

  [tyrosine 3-monooxygenase isoform b; Tyrosine 3-monooxygenase; tyrosine 3-monooxygenase; dystonia 14; tyrosine 3-hydroxylase; tyrosine hydroxylase; Tyrosine 3-hydroxylase; TH]

• NCBI GI Number:

  88900503

• NCBI Accession Number:

  NP_000351.2

• NCBI GB Accession Number:

  NM_000360.3

• Uniprot Accession Number:

  P07101

• CAS Number:

  9007-83-4