RABBIT ANTI HUMAN CD11c

RABBIT ANTI HUMAN CD11c

• CAS Number: 9007-83-4
• Gene Name: [CD11c]
• NCBI Gene ID: 3687
• Storage Conditions: Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.
• Specificity: This item detects human CD11c, also known as integrin alpha X (ITGAX). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. CD11c combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). CD11c is 150kD in size, and is expressed predominantly on tissue macrophages and dendritic cells.
  
  CD11c binds a myriad of ligands including cell adhesion molecules (e.g. ICAM-1, ICAM-4), bacterial cell wall components (LPS), complement protein (iC3b), and matrix proteins such as fibrogen and collagen. In light of this, CD11c has a number of functions including phagocytosis, cell migration, and cytokine production by macrophages/monocytes, as well as induction of T cell proliferation by Langerhans cells.
• Other Gene Names: [ITGAX; ITGAX; CD11C; SLEB6; CD11C]
• Short Name: [CD11c]
• Other Product Names: [integrin alpha-X isoform 2; Integrin alpha-X; integrin alpha-X; CD11 antigen-like family member C; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); leu M5, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; myeloid membrane antigen, alpha subunit; p150 95 integrin alpha chain; integrin, alpha X (complement component 3 receptor 4 subunit); CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c]
• NCBI GI Number: 34452173
• NCBI Accession Number: NP_000878.2
• NCBI GB Accession Number: NM_000887.4
• Uniprot Accession Number: P20702