RABBIT ANTI HUMAN INTERLEUKIN-23 (C-TERMINAL)

• NCBI Gene ID:

  51561

• Reactivity:

  Mouse

• Storage Conditions:

  Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.

• Specificity:

  This item detects an epitope within the C-terminal (CT) domain of human interleukin-23 (IL-23), a 21kD heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses.
  
  IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis.

• Other Gene Names:

  [IL23A; IL23A; P19; SGRF; IL-23; IL-23A; IL23P19; SGRF; IL-23 subunit alpha; IL-23-A; IL-23p19]

• Short Name:

  [IL-23]

• Other Product Names:

  [interleukin-23 subunit alpha; Interleukin-23 subunit alpha; interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; IL-23p19; JKA3 induced upon T-cell activation; interleukin 23 p19 subunit; interleukin-23 subunit p19; interleukin-six, G-CSF related factor; interleukin 23, alpha subunit p19; Interleukin-23 subunit p19; IL-23p19]

• NCBI GI Number:

  7706702

• NCBI Accession Number:

  NP_057668.1

• NCBI GB Accession Number:

  NM_016584.2

• Uniprot Accession Number:

  Q9NPF7

• CAS Number:

  9007-83-4