RABBIT ANTI BIK (N-TERMINAL)

• Gene Name:

  [BIK]

• NCBI Gene ID:

  638

• Reactivity:

  Mouse

• Storage Conditions:

  Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.

• Specificity:

  This item detects an epitope within the N-terminal (NT) region of Bcl-2-interacting killer (Bik) also known as natural born killer (Nbk). Bik is a Bcl-2 homology domain 3 (BH3)-only protein of 18kD which requires the BAX gene for activation. Bik forms heterodimers with various antiapoptotic proteins such as Bcl-2 and Bcl-XL, inhibiting their antiapoptotic function. This can result in the release of Ca2+ and cytochrome C into the cytosol, leading to apoptosis.
  
  Loss of Bik is a common feature of clear-cell renal cell carcinoma (RCC), and is thought to act as a renal tissue-specific tumour suppressor gene.

• Other Gene Names:

  [BIK; BIK; BP4; NBK; BIP1; NBK]

• Short Name:

  [BIK]

• Other Product Names:

  [bcl-2-interacting killer; Bcl-2-interacting killer; bcl-2-interacting killer; apoptosis inducer NBK; apoptosis-inducing NBK; BCL2-interacting killer (apoptosis-inducing); Apoptosis inducer NBK; BIP1; BP4]

• NCBI GI Number:

  4502411

• NCBI Accession Number:

  NP_001188.1

• NCBI GB Accession Number:

  NM_001197.4

• Uniprot Accession Number:

  Q13323

• CAS Number:

  9007-83-4