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GSK2837808A

CAT: 0013-GTR19157734-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157734-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively) . GSK2837808A inhibits lactate production in hypoxia but at higher concentrations than in normoxia (EC50=10 μM) . It also reduces ECAR (EC50=10 μM) . LDH inhibition by GSK2837808A alters multiple metabolic pathways in Snu398 cells. GSK2837808A rapidly and profoundly inhibits lactate production rates in multiple cancer cell lines including hepatocellular and breast carcinomas. GSK2837808A potency does not correlate with LDHA, LDHB, or the total LDH expression levels. The potency of GSK2837808A across 30 cancer cell lines with different LDHA and LDHB expression levels range from 400 nM to no effect (EC50 reported as 30 μM) .GSK2837808A (p.o.; 50 mg/kg in rats; 100 mg/kg in mice) treatment, causes blood compound levels at or below the detection limit of 2.5 ng/mL. Clearance following IV infusion of GSK2837808A at 0.25 mg/kg is displayed to be 69 mL/minute/kg in rats and it exceeds the animal liver blood flow.
CAS Number
1445879-21-9
Purity
>98% (HPLC)
Solubility
DMSO:95 mg/mL (146.24 mM)
Smiles
COc1ncc (-c2ccc3c (Nc4cc (Oc5cc (F) cc (F) c5) cc (c4) C (O) =O) c (cnc3c2) S (=O) (=O) NC2CC2) c (OC) n1
Molecular Formula
C31H25F2N5O7S
Molecular Weight
649.62
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

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T15435-01GSK2837808A
A20321-5GSK2837808A 5mg
A20321-1GSK2837808A 1mg
A20321-100GSK2837808A 100mg
A20321-25GSK2837808A 25mg
A20321-10GSK2837808A 10mg
HY-100681RGSK2837808A (Standard)
A20321-50GSK2837808A 50mg
A20321-2GSK2837808A 2mg
A20321-10mM-DGSK2837808A 10mM * 1mL in DMSO

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