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RABBIT ANTI HUMAN CD271

CAT: 0544-MBS221322-01Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS221322-01Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
[CD271]
NCBI Gene ID
4804
Reactivity
Mouse
Storage Conditions
Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Specificity
This item recognises CD271, a transmembrane protein of 70-75kDa, otherwise known as Nerve Growth Factor Receptor (NGFR). It is a pro-apoptotic member of the tumour necrosis factor receptor (TNFR) family and its ligands include NGF, brain derived growth neurotrophic factor (BDNF), NT3 and NT4.

CD271 has been shown to interact with tropomyosin-receptor-kinase A (TrkA) forming the high-affinity NGF receptor, while CD271 can signal alone, constituting the low-affinity NGF receptor. When signalling alone, CD271 is involved in apoptosis, neurite outgrowth during development and myelination.

Mutations and changes in CD271 expression have been implicated in various pathological diseases including Alzheimer's Disease, cerebral oedema and retinoblastoma.
Other Gene Names
[NGFR; NGFR; CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; TNFRSF16; NGF receptor]
Short Name
[CD271]
Other Product Names
[tumor necrosis factor receptor superfamily member 16; Tumor necrosis factor receptor superfamily member 16; tumor necrosis factor receptor superfamily member 16; NGF receptor; TNFR superfamily, member 16; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; p75 ICD; nerve growth factor receptor; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271]
NCBI GI Number
4505393
NCBI Accession Number
NP_002498.1
NCBI GB Accession Number
NM_002507.3
Uniprot Accession Number
P08138

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YLD1487-01Rabbit anti-CD271 Antibody
A110321Anti-CD271 (Rabbit, Monoclonal)
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