RABBIT ANTI BECLIN-1 (N-TERMINAL)

• NCBI Gene ID:

  114558

• Reactivity:

  Mouse, Rat

• Storage Conditions:

  Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.

• Specificity:

  This item recognises an epitope within the N-terminal region of Beclin-1, a 52kDa coiled-coil protein which shares structural homology with the yeast autophagy gene apg6/vps30.
  
  The ability of cells to undergo bulk degradation of endogenous proteins through an autophagosomic-lysosomal pathway, termed autophagy or Type II cell death, is important in the control of cell growth and development. Studies have identified Beclin-1 as a Bcl-2 interacting mammalian gene which not only mediates autophagy, but also functions as a tumour suppressor, being expressed at reduced levels in human breast carcinoma, and may also play a role in defense against viral infection. An increasing number of studies have revealed an interaction between proteins which induce autophagy and those involved in apoptosis and in some instances apoptosis may be dependant upon or delayed by autophagy.

• Other Gene Names:

  [Becn1; Becn1]

• Short Name:

  [BECLIN-1]

• Other Product Names:

  [beclin-1; Beclin-1; beclin-1; beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); coiled-coil myosin-like BCL2-interacting protein; beclin 1, autophagy related; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197]

• NCBI GI Number:

  77628041

• NCBI Accession Number:

  NP_001029289.1

• NCBI GB Accession Number:

  NM_001034117.1

• CAS Number:

  9007-83-4