RABBIT ANTI TSC1

• Gene Name:

  [TSC1]

• NCBI Gene ID:

  7248

• Reactivity:

  Mouse, Rat

• Storage Conditions:

  Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  Shelf Life: 18 months from date of despatch.

• Specificity:

  This item recognises an epitope within the internal region of the 130kDa tumour suppressor protein, Tumour sclerosis complex 1 (TSC1). Mutation within the TSC1 gene is responsible for Tuberous sclerosis (TSC), an autosomal dominant genetic disorder associated with the development of benign tumors (hamartomas), a condition also induced by mutation of the Tumour sclerosis complex 2 (TSC2) gene.
  Many proteins have been shown to play a role in the regulation of the serine/threonine kinase known as target of rapamycin (TOR), a central component in a complex signaling pathway which controls cell proliferation and cell cycle progression. Negative regulation of TOR activity occurs following the over-expression of the TSC1 and TSC2 gene products, hamartin and tuberin. These act by suppressing the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and ribosomal protein S6 kinase (S6K), downstream targets of TOR involved in mRNA translation. Furthermore the TOR activator protein Rheb has been identified as a target of TSC1-TSC2 complexes.
  
  This item has been reported as suitable for use in IHC on mouse EL4 cell cytospins at 2ug/ml.

• Other Gene Names:

  [TSC1; TSC1; LAM; TSC; KIAA0243; TSC]

• Short Name:

  [TSC1]

• Other Product Names:

  [hamartin isoform 1; Hamartin; hamartin; tuberous sclerosis 1 protein; tumor suppressor; tuberous sclerosis 1; Tuberous sclerosis 1 protein]

• NCBI GI Number:

  4507693

• NCBI Accession Number:

  NP_000359.1

• NCBI GB Accession Number:

  NM_000368.4

• Uniprot Accession Number:

  Q92574

• CAS Number:

  9007-83-4