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NDMC101

CAT: 0013-GTR19157729-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157729-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs) . Moreover, pit formation assay showed that NDMC101 significantly reduced the bone-resorbing activity of mature osteoclasts[1].In CIA mice, oral administration of NDMC101 reduced arthritic index and mitigated bone erosion. Serum TNF-α and IL-1β concentrations in these mice were decreased significantly at the higher dose of 62.5 mg/kg.
CAS Number
1308631-40-4
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (376.41 mM)
Smiles
Oc1ccccc1C (=O) Nc1ccc (Cl) cc1F
Molecular Formula
C13H9ClFNO2
Molecular Weight
265.66
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
MBS5759337NDMC101

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