(Arg) 9 TFA

(Arg) 9 TFA (Nona-L-arginine TFA), a cell-penetrating peptide, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.Poly-arginine (e.g. (Arg) 9) and arginine-rich peptides (e.g. TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. (Arg) 9 provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM) . Following kainic acid exposure, (Arg) 9 is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM) . (Arg) 9 also shows neuroprotection following in vitro ischemia (IC50=6 μM) . (Arg) 9) (D-isoform) is neuroprotective in rat stroke models. (Arg) 9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg) 9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after permanent middle cerebral artery occlusion (MCAO) reduces infarct volume.

2283335-13-5

Nona-L-arginine (TFA), Peptide R9 (TFA)

Immunology & Inflammation

>98% (HPLC)

H2O

OC (=O) C (F) (F) F.N[C@@H] (CCCNC (N) =N) C (=O) N[C@@H] (CCCNC (N) =N) C (=O) N[C@@H] (CCCNC (N) =N) C (=O) N[C@@H] (CCCNC (N) =N) C (=O) N[C@@H] (CCCNC (N) =N) C (=O) N[C@@H] (CCCNC (N) =N) C (=O) N[C@@H] (CCCNC (N) =N) C (=O) N[C@@H] (CCCNC (N) =N) C (=O) N[C@@H] (CCCNC (N) =N) C (O) =O

C56H111N36F3O12

1537.71

Storage temperature: -20°C. Stability: ≥ 2 years