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[Pyr1]-Apelin-13

CAT: 0013-GTR19157631-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157631-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
[Pyr1]-Apelin-13 is a potent and selective endogenous Apelin receptor (APJ) agonist.[Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1].[Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI.
CAS Number
217082-60-5
Product Name Alternative
[pGlu1]-Apelin-13
Purity
>98% (HPLC)
Solubility
H2O:50 mg/mL (32.60 mM)
Smiles
CSCCC (NC (=O) C1CCCN1C (=O) CNC (=O) C (CCCCN) NC (=O) C (CC1=CNC=N1) NC (=O) C (CO) NC (=O) C (CC (C) C) NC (=O) C (CCCNC (N) =N) NC (=O) C1CCCN1C (=O) C (CCCNC (N) =N) NC (=O) C1CCC (=O) N1) C (=O) N1CCCC1C (=O) NC (CC1=CC=CC=C1) C (O) =O
Molecular Formula
C69H108N22O16S
Molecular Weight
1533.8
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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