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Compstatin

CAT: 0013-GTR19157621-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157621-01Size:200 mg
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Description
Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans) ; Compstatin inhibits only the activation of primates' complement system.Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures. Pig xenografts survival is significantlylonger in the Compstatin perfused group than in the control group. At rejection the biopsy samples obtained from kidneysperfused with Compstatin show less deposition of C3 and fibrin than do the control kidneys.
CAS Number
206645-99-0
Purity
>98% (HPLC)
Solubility
DMSO:300 mg/mL (193.45 mM)
Smiles
CC[C@H] (C) [C@H] (N) C (=O) N[C@H]1CSSC[C@H] (NC (=O) [C@H] (CCCNC (N) =N) NC (=O) [C@H] (Cc2c[nH]cn2) NC (=O) [C@H] (Cc2c[nH]cn2) NC (=O) CNC (=O) [C@H] (Cc2c[nH]c3ccccc23) NC (=O) [C@H] (CC (O) =O) NC (=O) [C@H] (CCC (N) =O) NC (=O) [C@@H] (NC (=O) [C@@H] (NC1=O) C (C) C) C (C) C) C (=O) N[C@@H] ([C@@H] (C) O) C (N) =O
Molecular Formula
C66H99N23O17S2
Molecular Weight
1550.77
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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