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RAT ANTI MOUSE CD206

CAT: 0544-MBS215657-01Size: 0.25 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS215657-01Size:0.25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
[CD206]
NCBI Gene ID
17533
Reactivity
Mouse
Storage Conditions
Store at +4°C or at -20°C if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend microcentrifugation before use.
Specificity
Rat anti mouse CD206 antibody, clone MR5D3 recognizes the mouse mannose receptor, a ~175 kDa type 1 membrane glycoprotein that is also known as CD206. CD206 is expressed on most tissue macrophages, certain endothelial cells and in vitro derived dendritic cells (Zamze et al. 2002).

The mannose receptor, CD206, is composed of a N-terminal cysteine-rich domain, a fibronectin type II domain, eight tandemly arranged C-type lectin domains (CTLD), a transmembrane domain, and a cytoplasmic domain. The terminal cysteine-rich domain binds sulfated sugars, and the CTLD recognizes carbohydrates terminating in mannose, fucose and N-acetylglucosamine, all sugars found on microorganisms and on some endogenous proteins (Su et al. 2005).

Rat anti mouse CD206 antibody, clone MR5D3 has been reported to be non-inhibitory for the binding of the mannose receptor to carbohydrate ligands (Zamze et al. 2002). Clone MR5D3 has also been shown to work in Western Blot (Martinez-Pomares et al. 2003 and Su et al. 2005).
Other Gene Names
[Mrc1; Mrc1; MR; CD206; AW259686; MMR]
Short Name
[CD206]
Other Product Names
[macrophage mannose receptor 1; Macrophage mannose receptor 1; macrophage mannose receptor 1; MMR; mannose receptor, C type 1; CD_antigen: CD206]
NCBI GI Number
224967062
NCBI Accession Number
NP_032651.2
NCBI GB Accession Number
NM_008625.2

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