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MOUSE ANTI HUMAN CD300a

CAT: 0544-MBS214465-01Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS214465-01Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
[CD300a]
NCBI Gene ID
11314
Storage Conditions
Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Specificity
This item specifically recognises human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kDa transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells.

Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.
Other Gene Names
[CD300A; CD300A; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9; CMRF35H; IGSF12; CLM-8; CMRF35-H9; IgSF12; IRp60]
Short Name
[CD300a]
Other Product Names
[CMRF35-like molecule 8 isoform 2; CMRF35-like molecule 8; CMRF35-like molecule 8; CD300 antigen-like family member A; CD300a antigen; CMRF35H leukocyte immunoglobulin-like receptor; NK inhibitory receptor; immunoglobulin superfamily member 12; inhibitory receptor protein 60; leukocyte membrane antigen; CD300a molecule; CD300 antigen-like family member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; IgSF12; Inhibitory receptor protein 60; IRp60; NK inhibitory receptor; CD_antigen: CD300a]
NCBI GI Number
378786683
NCBI Accession Number
NP_001243770.1
NCBI GB Accession Number
NM_001256841.1
Uniprot Accession Number
Q9UGN4

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