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MOUSE ANTI HUMAN COMPLEMENT FACTOR H

CAT: 0544-MBS212919-02Size: 5x 0.1 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS212919-02Size:5x 0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
NCBI Gene ID
3075
Storage Conditions
Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Specificity
This item recognises human complement factor H which exists in 2 forms. The most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue.

Complement factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop.

Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.
Other Gene Names
[CFH; CFH; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; HF; HF1; HF2]
Short Name
[COMPLEMENT FACTOR H]
Other Product Names
[complement factor H isoform a; Complement factor H; complement factor H; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; age-related maculopathy susceptibility 1; beta-1-H-globulin; beta-1H; complement factor H, isoform b; factor H-like 1; complement factor H; H factor 1]
NCBI GI Number
62739186
NCBI Accession Number
NP_000177.2
NCBI GB Accession Number
NM_000186.3
Uniprot Accession Number
P08603

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