JOSAMYCIN

JOSAMYCIN is a macrolide antibiotic exhibiting antimicrobial activity. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM. (In Vitro) :Studies show that the average lifetime on the ribosome is 3 h for Josamycin and that the dissociation constants for Josamycin binding to the ribosome is 5.5 nM. Josamycin slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and completely inhibits formation of the second or third peptide bond, depending on peptide sequence at a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin. At a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin. (In Vivo) :Blood and tissue levels of Josamycin after oral administration are 200 mg/kg to rabbits. Tissue levels are generally much higher than the blood levels, and 3 h after the administration, when the blood level is very low, the tissue levels are rather higher than those 1 h after the dose. One hour after the medication, the level in the lungs is the highest of all the tissue levels.

16846-24-5

EN-141

Pharmacology & Drug Discovery

>98% (HPLC)

DMSO:41.67 mg/mL (50.33 mM)

CO[C@H]1[C@@H] (CC (=O) O[C@H] (C) C\C=C\C=C\[C@H] (O) [C@H] (C) C[C@H] (CC=O) [C@@H]1O[C@@H]1O[C@H] (C) [C@@H] (O[C@H]2C[C@@] (C) (O) [C@@H] (OC (=O) CC (C) C) [C@H] (C) O2) [C@@H] ([C@H]1O) N (C) C) OC (C) =O

C42H69NO15

827.99

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.