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AX20017

CAT: 0013-GTR19157285-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157285-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AX20017 is a small-molecule protein kinase G (PknG) inhibitor (IC50 : 0.39 μM) . It acts by blocking the proliferation of M. tuberculosis. (In Vitro) :The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis.
CAS Number
329221-38-7
Purity
>98% (HPLC)
Solubility
DMSO:32 mg/mL (121.06 mM)
Smiles
NC (=O) c1c (NC (=O) C2CC2) sc2CCCCc12
Molecular Formula
C13H16N2O2S
Molecular Weight
264.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (Cyclopropanecarbonylamino) -233a45677a-octahydro-1-benzothiophene-3-carboxamide

Alternative Products

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BA1355-25AX20017
A21226-25AX20017 25mg
A21226-5AX20017 5mg
A21226-100AX20017 100mg
A21226-10AX20017 10mg
A21226-2AX20017 2mg
A21226-50AX20017 50mg
A21226-10mM-DAX20017 10mM * 1mL in DMSO

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