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BMS-986165

CAT: 0013-GTR19157087-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157087-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-986165 is differentiated from previous JAK inhibitors due its unique ability to selectively bind to the pseudokinase (JH2) domain of TYK2 and inhibit its function through an allosteric mechanism.BMS-986165 maintains excellent potency in human and mouse whole blood (IC50s=13 and 100 nM, respectively) and shows no significant hERG inhibition in the flux assay (IC50>80 μM) .
CAS Number
1609392-27-9
Purity
>98% (HPLC)
Solubility
DMSO : 37.5 mg/mL (88.14 mM; Need ultrasonic)
Smiles
O=C (C1=NN=C (NC (C2CC2) =O) C=C1NC3=CC=CC (C4=NN (C) C=N4) =C3OC) NC ([2H]) ([2H]) [2H]
Molecular Formula
C??H??D?N?O?
Molecular Weight
425.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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