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LDH-IN-1

CAT: 0013-GTR19157045-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157045-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively. LDH-IN-1 inhibits the growth of MiaPaCa2 pancreatic cancer and A673 sarcoma cells with IC50s of 2.23 and 1.21 μM) . Dose response treatment of MiaPaCa-2 cells with LDH-IN-1 shows effects on cellular proliferation at concentrations as low as 250 nM and with nearly complete arrest of cell growth at 20 μM[1].LDH-IN-1 exhibits low nM inhibition of both LDHA and LDHB (IC50=32, 27 nM, respectively), submicromolar inhibition of lactate production, and inhibition of lactate in MiaPaCa2 pancreatic cancer and A673 sarcoma cells (IC50=0.517, 0.854μM, respectively) .LDH-IN-1 shows clearance values that far exceed hepatic blood flow in mouse species (90 mL/min/kg), with in vivo clearances of 227 mL/min/kg.
CAS Number
1964515-43-2
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/mL (87.61 mM; Need ultrasonic)
Smiles
O=S (C1=CC=C (CC2=C (N (C3=NC (C (O) =O) =CS3) N=C2C4=CC=CC (C5=CC=CC=C5) =C4) CC6CC6) C=C1) (N) =O
Molecular Formula
C30H26N4O4S2
Molecular Weight
570.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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Alternative Products

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MBS3612273-01LDH-IN-1
A19496-50LDH-IN-1 50mg
A19496-5LDH-IN-1 5mg
A19496-25LDH-IN-1 25mg
A19496-1LDH-IN-1 1mg
A19496-100LDH-IN-1 100mg
A19496-10LDH-IN-1 10mg
A19496-2LDH-IN-1 2mg
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