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Zoliflodacin

CAT: 0013-GTR19157000-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157000-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL) .Zoliflodacin has antibacterial activity against key Gram-positive, fastidious Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. Zoliflodacin stabilizes and arrests the cleaved covalent complex of gyrase with double-strand broken DNA under permissive conditions and thus blocks religation of the double-strand cleaved DNA to form fused circular DNA.
CAS Number
1620458-09-4
Product Name Alternative
ETX0914, AZD0914
Purity
>98% (HPLC)
Solubility
DMSO:135 mg/mL (276.95 mM; Need ultrasonic)
Smiles
[H][C@]12[C@H] (C) O[C@H] (C) CN1c1c (CC22C (=O) NC (=O) NC2=O) cc2c (noc2c1F) N1[C@@H] (C) COC1=O
Molecular Formula
C22H20FN5O7
Molecular Weight
487.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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