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Orelabrutinib

CAT: 0013-GTR19156994-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156994-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Orelabrutinib is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK) . (In Vitro) :With a proprietary formulation, Orelabrutinib (ICP-022) achieves high bioavailability comparing to other BTK inhibitors. (In Vivo) :Upon administration, Orelabrutinib (ICP-022) binds to and inhibits the activity of BTK. This prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK.
CAS Number
1655504-04-3
Product Name Alternative
ICP-022
Purity
>98% (HPLC)
Solubility
DMSO:250 mg/mL (584.80 mM; Need ultrasonic)
Smiles
NC (=O) c1ccc (nc1-c1ccc (Oc2ccccc2) cc1) C1CCN (CC1) C (=O) C=C
Molecular Formula
C26H25N3O3
Molecular Weight
427.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
BA8819-50Orelabrutinib
A22225-10Orelabrutinib 10mg
A22225-50Orelabrutinib 50mg
A22225-1Orelabrutinib 1mg
A22225-25Orelabrutinib 25mg
A22225-500Orelabrutinib 500mg
A22225-100Orelabrutinib 100mg
A22225-5Orelabrutinib 5mg
B2789-1Orelabrutinib (ICP-022)

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