WWL70

CAT: 0013-GTR19156949-01Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19156949-01Size:500 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM) . WWL70 (10 μM, 1 h) treatment, 2-Arachidonoylglycerol is increased by 20% compared to untreated cells. WWL70 (either 1 or 10 μM) completely blocks the lipopolysaccharide (LPS) -induced increase of PGE2. The enhanced mRNA expression of mPGES-1 and mPGES-2 by LPS is also reduced by WWL70. The IC50 of WWL70 to inhibit the PGE2 biosynthesis is about 100 nM.WWL70 treatment completely restores the ability of TBI mice to continuously alternate arms during Y maze exploration (69.67±4.98 %) . WWL70 treatment improves motor coordination of traumatic brain injury mice in a concentration-dependent manner. The latency to fall in animals treated with WWL70 (5 mg/kg) increases from 74.92±4.8 to 99.57±5.21 on day 3 (p<0.01) and from 87.32±4.42 to 100.14±3.56 on day 7 (p<0.05) post-injury when compare with the vehicle-TBI groups. WWL70 (10 mg/kg) treatment improves motor coordination starting on day 1 post-injury.

CAS Number

947669-91-2

Purity

>98% (HPLC)

Solubility

DMSO:17.33 mg/mL (39.61 mM; Need ultrasonic)

Smiles

CN (Cc1cccc (c1) -c1ccncc1) C (=O) Oc1ccc (cc1) -c1ccc (cc1) C (N) =O

Molecular Formula

C27H23N3O3

Molecular Weight

437.49

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Alternative Products

Catalog	Name
MBS3612370-01	WWL70
A15994-2	WWL70 2mg
A15994-50	WWL70 50mg
A15994-25	WWL70 25mg
A15994-5	WWL70 5mg
A15994-200	WWL70 200mg
A15994-100	WWL70 100mg
A15994-10	WWL70 10mg
A15994-10mM-D	WWL70 10mM * 1mL in DMSO

WWL70

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