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Miltirone

CAT: 0013-GTR19156945-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156945-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Miltirone is a CYPs inhibitor, it has been characterized as a low-affinity ligand for central benzodiazepine receptors.Miltirone inhibited multidrug-resistant P-glycoprotein (P-gp) -overexpressing CEM/ADR5000 cells better than drug-sensitive CCRF-CEM wild-type cells, a phenomenon termed collateral sensitivity. Flow cytometric analyses revealed that Miltirone induced G2/M arrest and apoptosis. Furthermore, Miltirone stimulated reactive oxygen species (ROS) generation and mitochondrial membrane potential (MMP) disruption, which in turn induced DNA damage and activation of caspases and poly ADP-ribose polymerase (PARP) . Downregulation of CCNB1 (cyclin B1) and CDC2 mRNA and upregulation of CDKN1A (p21) mRNA were in accord with Miltirone-induced G2/M arrest. Moreover, Miltirone decreased cell adherence to fibronectin. Molecular docking revealed that Miltirone bound to the ATP-binding site of IKK-β.
CAS Number
27210-57-7
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (177.07 mM)
Smiles
CC (C) C1=Cc2ccc3c (CCCC3 (C) C) c2C (=O) C1=O
Molecular Formula
C19H22O2
Molecular Weight
282.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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