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4-hydroxyphenyl acetate

CAT: 0013-GTR19156882-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156882-01Size:200 mg
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Description
4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer4-AC is a natural antioxidant, which demonstrates strong abilities to protect RPE cells from oxidative stress-induced necrosis. Mechanistically, 4-AC blocked the increase of cellular ROS induced by oxidative stress, and upregulated NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor. The NQO1, HO-1, and NRF2 were further shown to be required for 4-AC protection of RPE cells from death induced by tBHP. The tBHQ, an NRF2 stabilizer, consistently mimicked the protective effect of 4-AC against tBHP-induced RPE death.
CAS Number
3233-32-7
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (657.25 mM)
Smiles
CC (=O) Oc1ccc (O) cc1
Molecular Formula
C8H8O3?
Molecular Weight
152.15
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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