Brimonidine

• UNSPSC Description:

  Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist.

• Target Antigen:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Endocrinology; Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/uk-14,304.html

• Purity:

  99.99

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  BrC1=C2N=CC=NC2=CC=C1NC3=NCCN3

• Molecular Weight:

  292.13

• References & Citations:

  [1]Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.|[2]Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5.|[3]Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  59803-98-4