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EGFR-IN-7

CAT: 0013-GTR19156854-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156854-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-7 is a selective and potent EGFR kinase inhibitor.TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM respectively, and has similar enzymatic activity for EGFRWT (IC50 = 1.07) to Osimertinib. It also showed expected anti-proliferative activity in 4 cell lines, Ba/F3 (EGFRd746-750/T790M/C797S), NCI-H1975 (EGFRd746-750/T790M/C797S), PC9 (EGFRd746-750), and A431 (EGFRWT), with IC50 of 26.8, 163, 45, and 147 nM, respectively.
CAS Number
2267329-76-8
Product Name Alternative
TQB3804
Field of Research
Cell Biology
Purity
>98% (HPLC)
Solubility
DMSO:5 mg/mL (7.20 mM; ultrasonic and warming and adjust pH to 5 with 0.1 M HCL and heat to 60°C)
Smiles
COc1cc (N2CCC (CC2) N2CCN (C) CC2) c (C) cc1Nc1ncc (Br) c (Nc2ccc3nccnc3c2P (C) (C) =O) n1
Molecular Formula
C32H41BrN9O2P
Molecular Weight
694.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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BA6342-50EGFR-IN-7
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