LIT-001

CAT: 0013-GTR19156845-01Size: 1 gDry Ice: NoHazardous: No

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CAT#:0013-GTR19156845-01Size:1 g

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD) .

CAS Number

2245072-21-1

Purity

>98% (HPLC)

Solubility

DMSO:247 mg/mL (382.53mM; Need ultrasonic)

Smiles

OC (=O) C (F) (F) F.CN (C) C (=S) [C@@H]1CCCN1C (=O) NCc1ccc (cc1C) C (=O) N1Cc2cnn (C) c2Nc2ccccc12

Molecular Formula

C30H34F3N7O4S

Molecular Weight

645.7

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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BA5675-5.1	LIT-001
E0620-25mg	LIT-001 trifluoroacetate
555325	LIT-001 TFA
MBS5766988	LIT-001 free base
HY-124733	LIT-001 (free base)
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LIT-001

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