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TH1020

CAT: 0013-GTR19156795-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156795-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5) /Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.TH1020 was repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation. Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5. TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5.
CAS Number
1841460-82-9
Purity
>98% (HPLC)
Solubility
DMSO:2 mg/mL (4.41 mM; ultrasonic and warming and adjust pH to 2 with 1M HCl and heat to 80°C)
Smiles
C (c1ccccc1) n1c (Sc2ncnc3c4cccnc4sc23) nnc1-c1ccncc1
Molecular Formula
C23H15N7S2
Molecular Weight
453.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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