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Procyanidin B1

CAT: 0013-GTR19156763-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156763-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells. Procyanidin B1 (50-100 μM) protects against Aβ oligomer-induced neuronal death. Procyanidin B1 potently inhibits the activation of caspase-3 at 100 μM, caspase-8 at concentrations of 30, 50, and 100 μM and caspase-9 at concentrations of 10, 30, 50, and 100 μM. Procyanidin B1 (10, 20, 30 μM) significantly and dose-dependently induces expression of ACO and CPT1, with no obvious effect on mRNA expression of PPARα.
CAS Number
20315-25-7
Purity
>98% (HPLC)
Solubility
DMSO:23 mg/mL (39.76 mM; Need ultrasonic)
Smiles
O[C@H]1Cc2c (O) cc (O) c ([C@@H]3[C@@H] (O) [C@H] (Oc4cc (O) cc (O) c34) c3ccc (O) c (O) c3) c2O[C@@H]1c1ccc (O) c (O) c1
Molecular Formula
C30H24O12
Molecular Weight
578.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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