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Glucagon hydrochloride

CAT: 0013-GTR19156739-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156739-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glucagon hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon hydrochloride stimulates gluconeogenesis.Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis. Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia. Glucagon (100 nM) increases the phosphorylation of HNF4α. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes.Glucagon (20 μg/kg) increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice.
CAS Number
28270-04-4
Product Name Alternative
Porcine glucagon hydrochloride
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Smiles
Cl.CSCC[C@H] (NC (=O) [C@H] (CC (C) C) NC (=O) [C@H] (Cc1c[nH]c2ccccc12) NC (=O) [C@H] (CCC (N) =O) NC (=O) [C@@H] (NC (=O) [C@H] (Cc1ccccc1) NC (=O) [C@H] (CC (O) =O) NC (=O) [C@H] (CCC (N) =O) NC (=O) [C@H] (C) NC (=O) [C@H] (CCCNC (N) =N) NC (=O) [C@H] (CCCNC (N) =N) NC (=O) [C@H] (CO) NC (=O) [C@H] (CC (O) =O) NC (=O) [C@H] (CC (C) C) NC (=O) [C@H] (Cc1ccc (O) cc1) NC (=O) [C@H] (CCCCN) NC (=O) [C@H] (CO) NC (=O) [C@H] (Cc1ccc (O) cc1) NC (=O) [C@H] (CC (O) =O) NC (=O) [C@H] (CO) NC (=O) [C@@H] (NC (=O) [C@H] (Cc1ccccc1) NC (=O) [C@@H] (NC (=O) CNC (=O) [C@H] (CCC (N) =O) NC (=O) [C@H] (CO) NC (=O) [C@@H] (N) Cc1cnc[nH]1) [C@@H] (C) O) [C@@H] (C) O) C (C) C) C (=O) N[C@@H] (CC (N) =O) C (=O) N[C@@H] ([C@@H] (C) O) C (O) =O
Molecular Formula
C153H225N43O49S.ClH
Molecular Weight
3519.21
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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