BecloMethasone

BecloMethasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma. (In Vitro) :An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation.

4419-39-0

Beclometasone

>98% (HPLC)

DMSO:31 mg/mL (75.81 mM)

[H][C@@]12C[C@H] (C) [C@] (O) (C (=O) CO) [C@@]1 (C) C[C@H] (O) [C@@]1 (Cl) [C@@]2 ([H]) CCC2=CC (=O) C=C[C@]12C

C22H29ClO5

408.92

Storage temperature: -20°C. Stability: ≥ 2 years